Ingredients:
L-Theanine
Instead of acting as a sedative, L-theanine works to promote better rest by reducing anxiety and promoting relaxation. … In patients with major depressive disorder, the supplement ameliorated symptoms of anxiety and depression and improved sleep quality and cognitive function.
Magnesium Glutonate
The treatment of major depression (MD) is still a major unmet medical need in the majority of patients. Sixty percent of cases of MD are treatment-resistant depression (TRD), showing that classical treatments for MD are poorly effective to non-effective. Magnesium has been largely removed from processed foods, especially refined grains, in the Western world, harming the brain and causing mood disorders. Magnesium deficiency causes N-methyl-D-aspartate (NMDA) coupled calcium channels to be biased towards opening which causes neuronal injury and neurological dysfunction, which we believe results in MD. Oral administration of Mg to animals produced antidepressant-like effects that were comparable to those of antidepressant drugs.
5-HTP
5-Hydroxytryptophan (5-HTP) is an amino acid that your body naturally produces. Your body uses it to produce serotonin, a chemical messenger that sends signals between your nerve cells. Low serotonin levels are associated with depression, anxiety, sleep disorders, weight gain and other health problems (1Trusted Source, 2Trusted Source). Therefore, increasing your body’s production of serotonin may have various benefits. For this reason, serotonin-producing 5-HTP supplements have become increasingly popular.
Rhodilea Rosea
The new clinical trial comes from the University of Pennsylvania’s Perelman School of Medicine.
A team led by Jun Mao, M.D., conducted the first high-quality (randomized, double-blind, placebo-controlled) clinical trial to test rhodiola versus a top antidepressant drug.
Their study compared the effects of rhodiola versus those of the antidepressant drug sertraline (Zoloft) in 57 people with mild to moderate major depressive disorder (Mao JJ et al. 2015).
St John’s Wort
Several studies support the therapeutic benefit of St. John’s wort in treating mild to moderate depression. In fact, some research has shown the supplement to be as effective as several prescription antidepressants. But because St. John’s wort causes many drug interactions it might not be an appropriate choice, particularly if you take any prescription drugs.
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